When possessed either by angelic or demonic entities, the characters' meatsuit becomes host to the invading spirit, endowing the character with super powers commensurate to their current level of possession. During initial stages of possession, the original personality remains present but as the possession advances, the original personality will be supressed and eventually destroyed. Meatsuits are animated by the powers of the invading entity and glow with an aura based on the origin of the invading spirit.

If an invading angel or demon is exercised or banished, the original personality may return to its vessel. However, if neglected by the invading entity, or otherwise physically damaged, the meatsuit can be rendered lifeless if the spirit is expelled, as it is the power of the invading entity which animates the vessel.